When is the most effective time to administer growth hormone for idiopathic hypopituitarism?

The most effective time to administer growth hormone for idiopathic hypopituitarism is at bedtime. This timing aligns with the natural circadian rhythm of growth hormone secretion, which predominantly occurs during deep sleep. Administering growth hormone at night helps to maximize its efficacy, as it mimics the body's natural hormone release pattern, promoting optimal growth and metabolic effects.

Administering growth hormone in the morning or at midday may disrupt the natural hormonal rhythms, potentially reducing its effectiveness. Similarly, administering it before physical activity in the afternoon does not take advantage of the body's natural sleep cycles and might not yield the same beneficial effects on growth and development. Therefore, the preferred practice is to give growth hormone at bedtime to align treatment with the body's biological processes.